had been committed to vaccine production in chicken eggs. This had to be incubated with difficulty. This lasted for months.
was therefore impossible for it to respond to an acute exposure situation.
This has changed by a new trial. See untigen article.
was therefore impossible for it to respond to an acute exposure situation.
This has changed by a new trial. See untigen article.
first flu vaccine without eggs
cell culture vaccine on the market in 2007 will come / New method simplifies the production of vaccines
MARBURG (ice). About an established cell culture flu vaccine is spoken for years. Now, researchers from Novartis Behring in Marburg have achieved the first time such a vaccine. For the solemn inauguration of the plant even Chancellor Angela Merkel arrived in Marburg. The new vaccine is still end of the year in Germany and Austria on the market.
people working in medical professions, are sick more than 60 years of age or chronic, should be vaccinated against influenza each year. Photo: Novartis Behring
What does the new cell culture vaccine Optaflu ® with flu-protection? The immunogenicity of the new vaccine is indicated by the manufacturer as well as that of a conventional vaccine. The new vaccine contains purified antigens of the three influenza virus strains provided by WHO for this season.
In studies with more than 4,000 adult volunteers in Germany, Lithuania and Poland, the vaccine has proven to be safe and well tolerated. Local and systemic reactions to vaccination were generally similar between then and insignificant in the frequency and severity as in conventional vaccines. The new vaccine is approved for adults over 18.
new vaccine is for Allergy
Unlike conventional vaccines, the new vaccine is completely free from egg white. Thus, it now also allergic to egg protein should be vaccinated. Also, the vaccine contains no preservatives and stabilizers.
What is the main advantage of cell culture Grippeimpstoffs? The need for the vaccine Influenza viruses are grown in specific mammalian cells (from the kidney of a cocker spaniel). These cells float in a nutrient solution in large vessels (fermentors).
In conventional vaccines, however, the virus propagated in chicken embryos in eggs. For each dose of vaccine is a (steriles!) incubated hen necessary. to raise millions of such eggs for annual vaccine production is very expensive. Thus, for 23 million vaccine doses this year, consumes 18 football fields full of eggs pallets. The production of a conventional vaccine also lasts up to six months. If at that time suddenly encounter a new virus strain that is not covered by a conventional vaccine already in production, then for the current season, no custom conventional vaccines are manufactured.
The new cell culture vaccine is much simpler: the cells for the production are frozen and can reproduce any time and thaw. In an unexpectedly high demand or unforeseen vaccine virus strains can be quickly needed a new vaccine. The production can be saved, according to the Paul-Ehrlich-Institut in comparison to conventional vaccines for about two months.
U.S. Department of Health subsidized plant in the U.S.
This is a huge advantage for an influenza pandemic: Characterized from a worldwide epidemic, can very quickly a vaccine produced with a pandemic virus. For this reason, the U.S. Department of Health subsidized with 220 million dollar is identical with the Marburg plant production facility for cell culture vaccines. The plant of Novartis Vaccines produced in the U.S. state North Carolina.
will replace conventional cell culture vaccines in future vaccines? Other vaccine manufacturers are working to develop production processes for flu cell culture vaccines. It almost would have managed the company Baxter three years ago.
InfluJect The clinical development of the vaccine with the proposed trade name but had been stopped because of frequent vaccine reactions. In the long term cell culture vaccines are likely to replace conventional vaccines. In the next few years, it is also used by Novartis Vaccines remain over conventional vaccines Begrivac ® and Fluad ®.
the way, the first "flu" cases had already been. The winter will come. Prevention is better than complaining afterwards.
The flu vaccine is currently available.
This may soon change, however, because the industry is still not able to serve the market adequately.
Wolfgang Conzelmann Conzelmann
ambulance
Luxemburger Str 33 13353 Berlin
Phone: 461 79 23
Homepage:
http://www.arzt-berlin.tk/ or http://www.conzelmann.tk/
competence for practice sustainable medicine
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